This chapel contains a recently discovered stained glass ceiling in its attic. Cornerstone laying ceremonies for the massive Romanesque style church were held in 1899, with completion of the structure one year later. Architect Theodore C. Link was inspired for the church´s design by Henry Hobson Richardson´s famous Trinity Church in Boston. The St. Louis edifice is especially notable for its fine carving, ironwork and stained glass. In its interior the chancel has been changed several times.

Faced with the question of relocation in 1961, Second Presbyterian decided to remain at its present site and has since become involved in housing rehabilitation in its neighborhood.